About Prothena Corporation plc
Prothena Corporation plc is a late-stage clinical biotechnology company specializing in the discovery and development of novel therapies for diseases caused by protein dysregulation. Headquartered in Dublin, Ireland, the company was founded in 2012.
Key Product Pipeline
- Birtamimab – A humanized antibody in Phase 3 clinical trials for AL amyloidosis.
- Prasinezumab – A humanized monoclonal antibody in Phase 2b trials for Parkinson’s disease and other synucleinopathies.
- Coramitug – An investigational antibody in Phase 2 trials for transthyretin amyloidosis.
- BMS-986446 – An antibody in Phase 2 trials for Alzheimer’s disease.
- PRX012 – An investigational antibody in Phase 1 trials for Alzheimer’s disease.
- PRX123 – A Dual Aβ-Tau Vaccine in preclinical trials for Alzheimer’s disease.
- PRX019 – An investigational antibody in Phase 1 trials for neurodegenerative diseases.
Strategic Collaborations
Prothena has established key partnerships to advance its research:
- F. Hoffmann-La Roche Ltd. – License, development, and commercialization agreement for α-synuclein-targeting antibodies, including prasinezumab.
- Bristol Myers Squibb – Master collaboration agreement to develop antibodies targeting tau and TDP-43.